Triple-Negative Breast Cancer

Triple Negative Breast Cancer (TNBC) is an aggressive subtype of breast cancer that lacks estrogen, progesterone, and HER2 receptors, making it difficult to treat with traditional therapies. Precision AI is working to advance our ML algorithms to analyze large datasets of TNBC patients, identifying unique molecular signatures and potential therapeutic targets. By integrating genomic, proteomic, and clinical data, Precision AI aims to develop personalized treatment strategies that can improve outcomes for TNBC patients, ultimately advancing the field of oncology and offering new hope for those affected by this challenging disease.

The Problems

Aggressive biology. Few biomarkers. A need for better predictive treatment pathways

Aggressive Biology

Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer subtypes. It accounts for

15-20% of breast cancer diagnoses worldwide.

The 5-year survival rates drop to just

8-16% for patients with advanced-stages of the disease

Lacks Conventional Biomarkers

EREstrogen Receptor
PRProgesterone Receptor
HER2Human Epidermal-growth-factor Receptor 2

Limited Precision

Patient Impact

  • Increased toxicity exposure
  • Disease progression delays
  • Higher financial burden
  • Reduced survivability

Clinical Burden

  • Limited precision tools
  • Minimal guidance beyond NCCN
  • Case-by-case uncertainty

Equity & Underserved Populations

TNBC disproportionately impacts underserved populations, particularly black women who face worse outcomes and later diagnoses. Treatment initiation delays compound these disparities.

White women

35.5 days

Average time to treatment initiation

Black Women

62 days

Average time to treatment initiation

27-day delay — These extended treatment delays contribute significantly to worsened survival rates and highlight the critical need for equitable access to precision oncology solutions.

Our Approach

Precision AI's AI-powered transcriptome-wide treatment prediction

AI-Powered Transcriptome Analysis

Oncology CoPilot moves beyond limited biomarkers to analyze the entire tumor genome, enabling probability-ranked treatment recommendations grounded in systems-level molecular biology.

Whole Transcriptome Analysis

~20,000 coding genes for complete molecular profile

Network-Level Biology

Captures complex tumor biology beyond single markers

Clinically Annotated Reference

Compares against thousands of documented cancer cases

Integrated Analysis

Drug mechanisms, immunity, and microenvironment

Treatment Pathway Comparison

Watch how Oncology CoPilot streamlines patient care

Today's Standard of Care

Step 1
Patient Diagnosis
Step 2
Subtype confirmation
Step 3
Empirical therapy selection
Step 4
Monitor response
Step 5
Switch if ineffective

Each ineffective treatment cycle costs patients critical time

With Oncology CoPilot

Step 1
Patient Diagnosis
Step 2
NGS tumor profiling
Step 3
Probability-ranked report
Step 4
Begin first-line treatment

Confidence upfront. Fewer trial-and-error cycles.

By increasing confidence in treatment selection upfront,
Oncology CoPilot reduces avoidable trial-and-error cycles, enabling patients to begin well-informed, probability-ranked therapies from day one.

Ready to learn more?

Explore how Oncology CoPilot is transforming precision cancer care.
Oncology CoPilot